In 4,046 surveyed cases, drug dispensers mainly counselled on
special drugs or when being requested from patients. The counsel
content was dosage, usage, frequency and duration of administration.
This was partly due to the fact that the medical staffs thought that
patients had been counselled by physicians and patient prescriptions
had quite adequate instructions for using the drug, thus not paying
too much attention to such issue
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d therefore it is necessary to further study these parameters at the
central level.
6
+ Studies have investigated the economic aspects of drug use.
However, they have not assessed the relationship between rational
safety and economy.
+ Researchers have not comprehensively assessed the causes of
rational and safe use of drugs. Overcrowding in healthcare facilities
requires assessments and solutions.
+ Interventions and supervision in drug use have not been
thoroughly implemented. Researchers have not boldly intervened and
impacted the prescription system of drug use. Research is therefore
limited to warning levels for healthcare regulators.
* Regarding the research scope:
+ The problem that needs to be researched and resolved here is:
How do medical examination and treatment facilities operate, comply
with the regulations and guidelines, and effectively affect the
prescription and how to dispense drugs by healthcare workers
through information and counseling activities on drug use.
+ The medicine and treatment council has not been promoted in
hospitals, most of the activities are still faint and of a coping nature,
have not gone into analyzing the use and dispensing of drugs in
hospitals to propose remedies. No studies have analyzed the
interventions on the activities of the hospital medicines and treatment
Council and then re-evaluate the indicators of drug use as well as
rational use of drugs.
+ The main research topics on the subject are doctors,
pharmacists, while not evaluating and analyzing prescription.
CHAPTER 2.
SUBJECTS AND RESEARCH METHODS
2.1. Subjects
* 11 facilities that meet the research conditions.
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* Outpatient health insurance prescriptions during the study
period.
2.1.1. Patient selection criteria
* Public health facilities with health insurance holders; patients
and their relatives agree to participate in the study and fully answer
questions in the interview.
* Outpatient prescription with health insurance who encountered
common disease in the community.
2.1.2. Exclusion criteria
* Medical facilities, doctors at examination departments,
pharmacists dispensing drugs, patients and/or their family members
disagree to participate in the study.
* Patients who come for outpatient examination but are
transferred inpatient or emergency at a hospital.
2.2. Methods
2.2.1. Research designs
* Direct observation of prescription and dispensing activities.
* Direct interview of patients.
* Descriptive method with analysis before - after intervention.
2.2.2. Sample sizes
Based on the guidelines on survey of drug used index of WHO,
for each healthcare facility, at least 100 prescriptions were chosen,
according to the 2015-statistical table of Can Tho Social Insurance.
Can Tho University of Medicine and Pharmacy Hospital had the
lowest average number of daily outpatient visited, thus the sample
size wes 100 prescriptions. According to the corresponding ratio, the
number of prescriptions and insurance patients to be interviewed at
each facility is as follow:
8
Table 2.2. The number of samples to be divided according to
11 healthcare facilities
No. Healthcare Facilities
No. of
prescriptions
No. of
patients
1 Binh Thuy 136 136
2 Co Do 249 249
3 O Mon 681 681
4 Thot Not 630 630
5 Cai Rang 163 163
6 Phong Dien 303 303
7 Thoi Lai 377 377
8 Vinh Thanh 304 304
9 Can Tho Central General 218 218
10 CTUMP 100 100
11 Can Tho City General 885 885
Total 4,046 4,046
After intervention, samples with disease patterns, age group,
gender, education level are similar to those of before intervention.
The number of samples that needs to be collected at 3 healthcare
facilities after intervention is equal to that of before intervention.
2.2.4. Research content
2.2.4.1. Prescribing state in outpatient treatment with health
insurance at some public healthcare facilities in Can Tho city in the
period of 2016-2017
* Determining prescriptions to comply with the Minister of
Health's prescriptions for outpatient treatment.
* Prescription indicators: average number of prescriptions per
one prescription, percentage of drugs prescribed by generic or
international generic names (except for multi-ingredient medicines
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that can be prescribed under trade names), the proportion of
prescriptions with antibiotics, injectable drugs, vitamins,
corticosteroids, the proportion of prescription drugs included in the
list of essential drugs and the list of mainly drugs issued by the
MOH, and the proportion of drug interactions.
* Comprehensive drug use indicators: the average cost for each
prescription, ratio of antibiotics cost, ratio of injection cost, ratio of
vitamin cost, ratio of corticosteroids cost, prescription rates
consistent with the treatment regimen.
* Survey the validity of outpatient prescription practice:
The rationality in the practice of prescribing drugs is built
according to the definition in chapter 27.2 of the US Center for
Management of Health Sciences: reasonable indications, reasonable
doses (correct prescription dosage: single dose, 24-hour dose and
divided into the correct number of times – based on the medication
guide or the drug information online), reasonable route (based on the
medication guide or research online information about drugs),
appropriate treatment duration (not more than 30 days), reasonable
information for patients (full prescription information on instructions
for use, dosage, special notes) .
2.2.4.2. Evaluate the effectiveness of some interventions in
prescribing outpatient treatment with health insurance at some
public healthcare facilities in Can Tho city
* Interventions: educational solutions, enhancing knowledge
and promoting the rational dispensing of drugs.
* Evaluation of SCT:
Review the status of prescription: the compliance with
regulations on drug prescriptions, prescription indexes, rational use
of drugs have not been achieved at 3 healthcare facilities.
10
2.2.4.3. Evaluate the effectiveness of some interventions in
prescribing and taking care of outpatient at some public healthcare
facilities in Can Tho city
* 3 healthcare facilities: Can Tho university of Medicine and
Pharmacy hospital, O Mon district general hospital, Phong Dien
healthcare center.
* Subjects of intervention: council of medicines and treatment,
doctors prescribing outpatient drugs, pharmacists dispensing drugs
for outpatient treatment of health insurance.
* Observe the intervention solutions of state management
agencies in charge of health at 3 establishments.
* Assessing after intervetion: using T-test and Chi-square test to
compare differences of before intervetion and after intervetion.
2.2.4.4. Evaluate the effectiveness of some interventional solutions in
caring for outpatients who have health insurance at some public
healthcare facilities in Can Tho city
* Interventions: educational solutions, enhancing knowledge and
promoting the rational dispensing of drugs.
* Evaluation of SCT:
Review the status of patient care: patient care index, patient
satisfaction with outpatient services have not been achieved at 3
healthcare facilities.
2.2.5. Methods of processing and analyzing data
Data were processed using SPSS 20.0 software.
Chapter 3.
RESULTS
3.1. Results of assessing the status of prescription and the
effectiveness of some interventions in prescribing outpatient
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health insurance drugs at some public health facilities in Can
Tho city in the period of 2016- 2018
3.1.1. Results of assessing the situation of prescribing for
outpatient health insurance at some public health facilities in
Can Tho city in the period of 2016-2017
3.1.1.1. Survey results on compliance with outpatient prescriptions
* Regarding compliance with administrative procedures
regulations: the implementation of the provisions on administrative
procedures needed in a prescription is quite well implemented (4/5
requests reach 100%), although there are still errors in recording
patient's home address, only reaching average overall 88.3%, the
error is usually due to missing address details or sometimes writing
the name of the patient's work agency.
* Regarding the compliance with the prescriptions: the
percentage of correct implementation of regulations on compulsory
contents in a prescription: 89.8% have correct full contents of the
prescription, 96% have correct number of medicines.
3.1.1.2. Assessment results in prescription index
* The average number of prescription drugs in a single
prescription: The average for all survey samples is 5.00.
* The proportion of drugs prescribed by the generic name and
international common name: Cai Rang district general hospital is the
only facility that does not achieve absolute success with 85.32%. In
which, 3 most pharmaceuticals were listed without the active
ingredient names are Apitim (amlodipine) (12.55%), Domitral
(nitroglycerin) (11.63%), and Detracyl (mephenesin) (6.36%).
* The proportion of applications with antibiotics: The average
number of applications with antibiotics is 31.1%. Antibiotics was
initially selected for the treatment of gastrointestinal, respiratory,
urology, mainly the β-lactam group.
12
* The ratio of applications having injections: the general
percentage is 0.9%.
* The ratio of applications vitamins: the rate is 24.7%.
* The proportion of applications with corticosteroids: the
general rate for 11 health facilities is 12.1%. Phong Dien district
healthcare center accounted for the highest rate of 22.8% and the
lowest rate belonged to Can Tho University of Medicine and
Pharmacy Hospital with 4.0%. Prednisolone and Methyl
prednisolone are 2 corticosteroids usually used by doctors.
* The percentage of prescription drugs included in Essential
drug list and Main drug list: the average percentage of Essential drug
used is 41.98% and Main drug is 63.07%.
3.1.2. Evaluate the effectiveness of some interventions in
prescribing for outpatient at some public healthcare facilities in
Can Tho city in the period of 2017-2018
3.1.2.1. Compliance with regulations in prescribing for outpatient
After the intervention, the percentage of compliance with the
regulations on correct addressing in O Mon district general hospital
was increased but it was not significant. This index in Can Tho
university of Medicine and Pharmacy hospital and Phong Dien
healthcare center had a significant increase with p < 0.05 when Can
Tho university of Medicine and Pharmacy hospital increased from
85.0% to 100.0% and Phong Dien district healthcare center increased
from 90.8% to 100.0%. Requirements on recording drug quantity less
than 10 compliance rate after intervention at Can Tho university of
Medicine and Pharmacy hospital has changed but not significant with
p > 0.05. Particularly, Phong Dien district healthcare center had a
statistically significant increase with p < 0.05 in the regulation on
drug name, concentration/content, quantity, dose, route, time of use
of each drug from 62.7% to 93.2%.
13
3.1.2.2. Prescription indicators
* Average number of drugs in a prescription after intervention:
Table 3.24. The average number of drugs in a prescription
after intervention
No. Health facility
No.
of
pres.
Quartile
p
Q25 Q50 Q75
1 CTUMP
Before 100 3 4 5
> 0.05
After 100 3 4 5
2 O Mon
Before 681 4 4 4
< 0.05
After 681 4 4 5
3
Phong
Dien
Before 303 5 6 6
> 0.05
After 303 5 6 6
The average of total number of drugs prescribed by O Mon
district general hospital increased significantly after intervention
from 4.00 to 5.00 drugs in a single prescription with p < 0.05 and
Q75, however this increase is not clinically significant.
3.2. Results of assessing the situation of patient care and the
effectiveness of some interventions in taking care of patients with
outpatient health insurance at some public health facilities in
Can Tho city in 2016 -2018
3.2.1. Results of the assessing the situation of taking care of
patients with outpatient medical insurance in some public health
facilities in Can Tho city in the period of 2016-2017
3.2.1.1. Patient care indicators
* Average medical examination time: the lowest and highest
medical examination time in each hospital was 0.2 minutes and 33.10
minutes, respectively. The overall average for this study is 2.64
minutes.
14
* Average dispensing time: this research result is high, however,
in our opinion, it is mainly the waiting time at the health insurance
dispensing office due to the large number of patients rather than the
direct communication time between allocation staff and patients.
* The percentage of drugs actually distributed: the average
percentage of actually distributed at 11/11 health facilities is almost
absolute, reaching 99.96%.
* The percentage of fully labeled applications: the percentage of
labeled drugs is as low as 47%.
* The patients' understanding of using dose: knowledge about
the duration of treatment is 77.1%, how to use the medicine is 76.4%,
the dosage of each type of medicine is 75.3%, the time to use
medicine is 76.7%.
3.2.1.2. Patient satisfaction in healthcare service
Regarding accessibility, the average of level 4 and level 5 at 11
health facilities was quite high, at 71.58%. Information transparency
and procedures to achieve satisfaction level of 4 or more with the rate
of over 80% in 3 health facilities: Phong Dien district healthcare
center, Cai Rang district healthcare center, Thoi Lai district
healthcare center. The average percentage of 11 medical facilities
was 71.77%. The attitude and professional capacity of health workers
at the survey facilities is assessed to be quite high.
3.2.2. Evaluate the effectiveness of some interventions in
outpatient care in some public health facilities in Can Tho city in
the period of 2017-2018
3.2.2.1. Patient care indicators
* Average time of examination: after intervention, time of
examination in all 3 hospitals increased significantly with p < 0.05.
Can Tho university of Medicine and Pharmacy increased from 2.50
minutes to 5.09 minutes, O Mon district general hospital increased
15
from 2.25 minutes to 4.62 minutes and Phong Dien district healthcare
center increased from 1.88 minutes to 3.93 minutes. It can be said
that the interventions are somehow effective.
* Average delivery time:
Table 3.37. Average drug delivery time after intervention
No. Health facility
No. of
pres.
Quartile
p
Q25 Q50 Q75
1 CTUMP
Before 100 5.24 5.8 6.33
< 0.05
After 100 5.77 6.29 6.53
2 O Mon
Before 681 4.75 6.58 7.83
< 0.05
After 681 6.34 7.65 9.68
3
Phong
Dien
Before 303 2.43 3.1 5.5
< 0.05
After 303 5.45 6.07 6.42
Similar to the time of examination, the time of drug dispensing
also increased to statistical significance with p < 0.05. This is also a
good sign to prove the effectiveness of interventions.
* The percentage of prescription which drugs fully labeled after
intervention: significant increase in all 3 hospitals with p < 0.05. This
improvement is significant with Can Tho university of Medicine and
Pharmacy hospital increasing from 30% to 51%, O Mon district
general hospital from 16.7% to 36.1% and Phong Dien district
healthcare center from 35% to 55.1 %.
* Patient's understanding of their treatment: the patient's
knowledge about 4 surveyed variables increased, but mostly not
statistically significant.
3.2.2.2. Patient satisfaction with health care service
Regarding the provision of medical services, there was a
decrease in the percentage of high level of satisfaction at O Mon
district general hospital, a slight increase at the two other hospitals,
but the increase or decrease mostly did not have statistical
16
significance. The majority of patients' satisfaction with accessibility
increased after intervention, Phong Dien district healthcare center
increased the highest by 12.28%, Can Tho university of Medicine
and Pharmacy hospital increased by 8% and O Mon district general
hospital increased by 3.08%. The transparency of information and
procedures with the highest satisfaction rate among patients going to
outpatient health insurance after intervention and highest at Can Tho
university of Medicine and Pharmacy hospital with all the variables
are statistically significant. In terms of facilities, this hospital also
had a statistically satisfaction in high level. In terms of attitude, the
professional competence of employees with high satisfaction rate has
decreased but not much, most of them are not statistically significant
(p > 0.05).
CHAPTER 4.
DISCUSSION
4.1. Situation of prescribing and effectiveness of some
interventions in prescribing health insurance drugs for
outpatients at public health facilities in Can Tho city during the
period of 2016-2018
4.1.1. Situation of prescribing health insurance drugs for
outpatients at public health facilities in Can Tho city during the
period 2016-2017
4.1.1.1. Compliance with regulations on outpatient prescription
* Compliance with regulations on administrative procedures:
Insufficient addressing was due to a variety of reasons. For
example, with regard to disregarded information, doctors who have
to deal with a great number of patients might think that such
administrative regulations do not affect the examination results and
thereby ignoring information about patients.
* Compliance with regulations on content of prescriptions:
17
The analysis of results showed that the processes of
disseminating and guiding the regulations on prescription for doctors
have not been synchronized. In addition, the dispensing of drugs in
the Department of Pharmacy only focused on considering the
appropriateness of prescribed drugs rather than focus on other
provisions of the prescription regulations. Therefore, doctors were
still subjective and ignored regulations on content of prescriptions.
4.1.1.2. Prescription indicators
* The average number of drugs in a prescription:
Prescriptions had a high number of drugs because most patients
suffered from many diseases. The most common ICD codes were
typical conditions of the elderly namely I10-idiopathic hypertension
(15.7%), K29-gastritis, duodenitis (9.35%), E11-Non Insulin
Dependent Diabetes Mellitus (7.29%).
* The rate of drugs prescribed under generic or international
generic names:
The application of information technology to prescriptions may
overcome the problem of prescribing with non-generic name.
Particularly, in Cai Rang district health center, the percentage of
drugs prescribed with generic name was the lowest, at 71.66%. The
reason was that the Faculty of Pharmacy did not closely follow the
regulations when sending the list of drugs to the IT department. As a
result, some single substance drugs were put on the software without
their active substance name, which led to the situation of doctors
prescribing brand names. Therefore, such rate did not meet the
WHO's recommendations.
* The rate of prescription with antibiotics:
The reason for the differences among health facilities was that
the disease patterns of prescription drugs in surveyed samples were
not the same. In-depth analysis of antibiotic combinations, cases of
18
using 2 or 3 antibiotics mainly combined 2 drugs with different forms
of use, mainly oral and ophthalmic eye drops antibiotic or topical
antibiotic or according to the treatment regimen of H. pylori stomach
ulcers.
* The rate of prescription with injecting medicine:
Results showed that the healthcare facilities did not abuse this
kind of drug. The reason why there were 5 medical facilities which
did not use injecting drugs in the list of outpatient health insurance
drugs was that they were graded III in the classification of healthcare
facilities. Therefore, the permissible health insurance ceilings were
lower. Injecting drugs were high-cost drugs; therefore, in 5 health
facilities, they were only in the list of inpatient medical insurance
drugs.
* The rate of prescription with vitamins:
According to WHO, this indicator does not have ideal level
which was researched by the Ministry of Health of Vietnam and a
number of countries to monitor the use of vitamins in prescription, as
well as to avoid overuse of vitamins.
* The rate of prescription with corticosteroids:
The corticosteroids in the survey were mainly used for the
treatment of inflammation, asthma or topical application in topical
products. None of the corticosteroids were abused or misused based
on diagnoses.
* The rate of prescribed drugs in essential medicine list and
main medicine list:
The percentage of prescription drugs in surveyed facilities’
essential medicine list/main medicine list was low. Doctors were only
allowed to prescribe drugs in the presented lists; therefore, it was
seen that the cause of low rate of prescribed drugs in essential
medicine list and main medicine list was not from doctors.
19
4.1.2. Effectiveness of some interventions in prescribing
medicines for outpatients at public health facilities in Can Tho
city during the period of 2017-2018
4.1.2.1. Compliance with regulations on prescribing for outpatients
Interventions such as promoting the implementation of
regulations, educating and enhancing knowledge by directly
propagandizing regulations on prescriptions, distributing materials
and regularly reminding during professional meetings has effectively
impacted on the awareness and strict adherence to the regulations
regarding prescribing.
4.1.2.2. Prescription indicators
* The average number of drugs in a prescription:
This result also highlighted the need to raise awareness of
physicians about prescription. Medical facilities should have
measures for prescribers to be able to calculate the cost of medicine
right after prescribing so that they can adjust the price of
prescriptions in accordance with the affordability of the patients as
well as the health insurance provisions.
4.2. Situation of patient health care and effectiveness of some
interventions in healthcare of outpatients with health insurance
at some public health facilities in Can Tho city during the period
of 2016-2018
4.2.1. Situation of patient health care at some public health
facilities in Can Tho city during the period of 2016-2018
4.2.1.1. Patient health care indicators:
* Average time for medical examination:
This indicator was not achieved because the state healthcare
facilities in Vietnam in general and Can Tho in particular, especially
district healthcare facilities, with relatively few facilities and the lack
of human resources, which led to overcrowding. In addition, doctors
20
who were not only in charge of medical examination and treatment,
but also had to carry out other administrative tasks, thus having a
great work pressure which partly limited the effectiveness of medical
examination and treatment.
* Average drug dispense time:
In 4,046 surveyed cases, drug dispensers mainly counselled on
special drugs or when being requested from patients. The counsel
content was dosage, usage, frequency and duration of administration.
This was partly due to the fact that the medical staffs thought that
patients had been counselled by physicians and patient prescriptions
had quite adequate instructions for using the drug, thus not paying
too much attention to such issue.
* The rate of drugs actually distributed:
Drug management software provided by Hau Giang
Pharmaceutical Joint-Stock Company was used by 11 health facilities
surveyed. Accordingly, only drugs in the warehouse were included in
the drug list. Doctors prescribed based on such software and
Pharmaceutical department did not have to notify the status of
existing drugs to the departments.
* The rate of sufficiently labelled prescriptions:
This result was low due to the pressure and workload during
hospital busiest hours when continuous drug dispenses interfered
with the preparation of adequate information on drug use instructions
in the patient medicine bags. Moreover, the majority of dispensers
believed that most of information was already on patient
prescriptions so labelling was not necessary and patients only have to
follow drug use on the prescription. Instead of writing in detail,
verbal instructions were given to patients.
* Patient understanding of
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